Clinical Comparison
Wegovy vs Zepbound
A definitive analysis of two leading GLP-1 / GIP medications for chronic weight management. Evaluated for efficacy, cost-efficiency, and side-effect profile.
The Bottom Line
Choose Wegovy if you have insurance coverage and want the longest safety track record. Choose Zepbound if you're cash-pay and want maximum average weight loss.
Spec by Spec
| Spec | Wegovy | Zepbound |
|---|---|---|
| Avg weight loss (72 weeks) | 15% | 22.5% |
| Monthly cost (cash pay) | $1,349 | $1,059 |
| FDA approval | 2021 | 2023 |
| Dosing | Weekly injection | Weekly injection |
| Most common side effects | Nausea, constipation | Nausea, fatigue |
Cash-pay path
Best with compounded alternatives or telehealth bulk pricing
Insurance path
Choose a clinic with prior-auth concierge