Wegovy vs Compounded Tirzepatide
A side-by-side look at two GLP-1 options for chronic weight management — efficacy, cost, dosing, and side-effect profile.
Last updated July 2026 · TrimSoMo Editorial Team
Wegovy (GLP-1 receptor agonist) and Compounded Tirzepatide (GLP-1 / GIP dual agonist) are both used for weight management. Wegovy is fDA-approved for weight management (2021); Compounded Tirzepatide is not FDA-approved; compounded — availability restricted in 2026. List prices run ~$1,349/mo list vs ~$250–$500/mo. The right choice depends on insurance coverage, how you tolerate side effects, and whether you prefer an injection or an oral option — decide with a licensed provider.
Spec by Spec
| Spec | Wegovy | Compounded Tirzepatide |
|---|---|---|
| Drug class | GLP-1 receptor agonist | GLP-1 / GIP dual agonist |
| How you take it | Weekly injection | Weekly injection |
| Avg weight loss (trials) | ~15% of body weight (STEP-1, 68 weeks) | Comparable to tirzepatide (~20%); varies by formulation |
| Monthly cash price | ~$1,349/mo list | ~$250–$500/mo |
| FDA status (weight) | FDA-approved for weight management (2021) | Not FDA-approved; compounded — availability restricted in 2026 |
| Common side effects | Nausea, diarrhea, constipation, vomiting | Nausea, diarrhea, fatigue |
Compounded Tirzepatide: Restricted in 2026 to documented medical need; choose LegitScript-verified pharmacies.
Wegovy cost guide
Full price breakdown and ways to save
Compounded Tirzepatide cost guide
Full price breakdown and ways to save
Frequently Asked Questions
Is Wegovy or Compounded Tirzepatide more effective for weight loss?
Wegovy: ~15% of body weight (STEP-1, 68 weeks). Compounded Tirzepatide: Comparable to tirzepatide (~20%); varies by formulation. These figures come from separate manufacturer trials, not a direct head-to-head study, so compare them as ranges rather than exact head-to-head results.
Which is cheaper, Wegovy or Compounded Tirzepatide?
List prices are roughly ~$1,349/mo list for Wegovy and ~$250–$500/mo for Compounded Tirzepatide. Your real out-of-pocket cost depends on insurance, manufacturer savings programs, telehealth pricing, and (where appropriate) compounded options.
Can I switch between Wegovy and Compounded Tirzepatide?
Switching GLP-1 medications is common and should be done under a prescriber's guidance, who manages dose titration to limit nausea and other GI side effects.
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Disclaimer: Figures are approximate, drawn from manufacturer trials and published list prices, and are not a direct head-to-head study or medical advice. Consult a licensed provider before starting or switching any GLP-1 medication.