Ozempic vs Mounjaro
A side-by-side look at two GLP-1 options for chronic weight management — efficacy, cost, dosing, and side-effect profile.
Last updated July 2026 · TrimSoMo Editorial Team
Ozempic (GLP-1 receptor agonist) and Mounjaro (GLP-1 / GIP dual agonist) are both used for weight management. Ozempic is fDA-approved for type 2 diabetes (2017); weight loss is off-label; Mounjaro is fDA-approved for type 2 diabetes (2022); weight loss is off-label. List prices run ~$969/mo list vs ~$1,069/mo list. The right choice depends on insurance coverage, how you tolerate side effects, and whether you prefer an injection or an oral option — decide with a licensed provider.
Spec by Spec
| Spec | Ozempic | Mounjaro |
|---|---|---|
| Drug class | GLP-1 receptor agonist | GLP-1 / GIP dual agonist |
| How you take it | Weekly injection | Weekly injection |
| Avg weight loss (trials) | ~6–14% (off-label; varies by dose) | ~15–21% (off-label; varies by dose) |
| Monthly cash price | ~$969/mo list | ~$1,069/mo list |
| FDA status (weight) | FDA-approved for type 2 diabetes (2017); weight loss is off-label | FDA-approved for type 2 diabetes (2022); weight loss is off-label |
| Common side effects | Nausea, vomiting, diarrhea | Nausea, diarrhea, decreased appetite |
Ozempic cost guide
Full price breakdown and ways to save
Mounjaro cost guide
Full price breakdown and ways to save
Frequently Asked Questions
Is Ozempic or Mounjaro more effective for weight loss?
Ozempic: ~6–14% (off-label; varies by dose). Mounjaro: ~15–21% (off-label; varies by dose). These figures come from separate manufacturer trials, not a direct head-to-head study, so compare them as ranges rather than exact head-to-head results.
Which is cheaper, Ozempic or Mounjaro?
List prices are roughly ~$969/mo list for Ozempic and ~$1,069/mo list for Mounjaro. Your real out-of-pocket cost depends on insurance, manufacturer savings programs, telehealth pricing, and (where appropriate) compounded options.
Can I switch between Ozempic and Mounjaro?
Switching GLP-1 medications is common and should be done under a prescriber's guidance, who manages dose titration to limit nausea and other GI side effects.
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Disclaimer: Figures are approximate, drawn from manufacturer trials and published list prices, and are not a direct head-to-head study or medical advice. Consult a licensed provider before starting or switching any GLP-1 medication.